Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440294 | 0.85 | MME (0.53) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL4442570 | 0.84 | MME (0.78) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL3876977 | 0.74 | ALDH1A1 (0.58) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9289006 | 0.73 | MME (0.70) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL7618807 | 0.73 | MME (0.70) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL13821843 | 0.73 | CTSL (0.49) | ALDH1A1PNMTCTSVCTSLCTSB | |
| SCHEMBL7334041 | 0.73 | MME (0.72) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL7334044 | 0.73 | MME (0.72) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL9724958 | 0.73 | MAPT (0.62) | MMEACEALDH1A1HPGDMAPK1 | |
| Thiorphan SCHEMBL401174 | 0.72 | MME (1.00) | MMEACEALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132187-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008097459-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-08-14 | — | — | WO | disclosed |