Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | CCR3 | P51677 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608160 | 0.93 | DRD3 (0.59) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4443660 | 0.82 | HRH3 (0.60) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3289104 | 0.80 | HRH3 (0.68) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL16382665 | 0.80 | SLC6A2 (0.57) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4227255 | 0.79 | HRH3 (0.67) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL11457969 | 0.79 | DRD3 (0.56) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4236282 | 0.78 | DRD2 (0.61) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL6496199 | 0.76 | SLC6A2 (0.66) | SLC6A2SLC6A3SLC6A4HRH3HRH1 | |
| SCHEMBL26049997 | 0.76 | SLC6A2 (0.66) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL24394537 | 0.75 | ALDH1A1 (0.62) | DRD2SLC6A2SLC6A3SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121703-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008020799-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |