Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440335 | 0.93 | DRD3 (0.52) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3289104 | 0.86 | HRH3 (0.68) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL16382665 | 0.86 | SLC6A2 (0.57) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4227255 | 0.85 | HRH3 (0.67) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL11457969 | 0.85 | DRD3 (0.56) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4236282 | 0.84 | DRD2 (0.61) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL6496199 | 0.81 | SLC6A2 (0.66) | SLC6A2SLC6A3SLC6A4HRH3HRH1 | |
| SCHEMBL26049997 | 0.81 | SLC6A2 (0.66) | DRD3DRD2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL24394537 | 0.81 | ALDH1A1 (0.62) | DRD2SLC6A2SLC6A3SLC6A4HRH3 | |
| SCHEMBL13452625 | 0.81 | ALDH1A1 (0.49) | ALDH1A1CYP2D6CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723331-B2 | Thienopyrimidine compounds and uses thereof | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| EP-2121703-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| US-20080051405-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | disclosed |
| WO-2008020799-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051405-A1 | Therapeutic Agents | GPR119, HTT, IAPP | DRD3 2558/4885DRD2 1842/4885SLC6A2 1701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.