Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434672 | 0.89 | PPARG (0.41) | FFAR1ACP3CACNA1ACACNA2D1CACNB1 | |
| SCHEMBL6703510 | 0.82 | ACP3 (0.51) | ACP3KIF11CACNA1ACACNA2D1CACNB1 | |
| SCHEMBL4433877 | 0.80 | ACP3 (0.39) | FFAR1ACP3CACNA1ACACNA2D1CACNB1 | |
| SCHEMBL4441831 | 0.80 | CASR (0.35) | MMP2MMP9ACP3CACNA1ACACNA2D1 | |
| SCHEMBL23960436 | 0.74 | CYP19A1 (0.46) | FFAR1ACP3CACNA1ACACNA2D1CACNB1 | |
| SCHEMBL4441719 | 0.74 | AKR1C3 (0.46) | — | |
| SCHEMBL25954028 | 0.72 | CHRM2 (0.41) | CETPCHRM2CHRM1CHRM3GPR139 | |
| SCHEMBL4970158 | 0.70 | GPR139 (0.50) | CETPTRPM8CTSAGPR139 | |
| SCHEMBL22089163 | 0.69 | CTSA (0.53) | TRPM8FFAR1CTSA | |
| SCHEMBL25336167 | 0.69 | CHRM2 (0.39) | CETPCHRM2CHRM1CHRM3GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |