Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440422 | 0.89 | CETP (0.43) | FFAR1CACNA1CCACNA1ACACNA2D1CACNB1 | |
| SCHEMBL6703510 | 0.81 | ACP3 (0.51) | CACNA1CCACNA1ACACNA2D1CACNB1CACNA1B | |
| SCHEMBL4433877 | 0.79 | ACP3 (0.39) | PPARGFFAR1CACNA1CCACNA1ACACNA2D1 | |
| SCHEMBL4431369 | 0.74 | MEN1 (0.43) | PPARGPPARAFFAR1MEN1LMNA | |
| SCHEMBL22965330 | 0.74 | DRD1 (0.46) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL23960436 | 0.73 | CYP19A1 (0.46) | FFAR1CACNA1CCACNA1ACACNA2D1CACNB1 | |
| SCHEMBL4441719 | 0.73 | AKR1C3 (0.46) | PPARGPPARAMEN1KMT2A | |
| SCHEMBL4435507 | 0.72 | KDM4E (0.45) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4431243 | 0.72 | KDM4E (0.45) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4431325 | 0.72 | KDM4E (0.45) | MEN1LMNAHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |