Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 2/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703510 | 0.85 | ACP3 (0.51) | ACP3CACNA1ACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL6699162 | 0.85 | ACP3 (0.47) | ACP3CASRCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL1581317 | 0.81 | PNMT (0.45) | ACP3CASRFFAR2GRIN2BCACNA1C | |
| SCHEMBL4440422 | 0.80 | CETP (0.43) | ACP3CACNA1ACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL4434672 | 0.79 | PPARG (0.41) | ACP3CACNA1ACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL23960436 | 0.77 | CYP19A1 (0.46) | ACP3CACNA1ACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL27614458 | 0.77 | LMNA (0.36) | ACP3CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL6339476 | 0.75 | PPARG (0.39) | PPARGOPRL1CNR1CNR2 | |
| SCHEMBL4441831 | 0.75 | CASR (0.35) | ACP3CASRCACNA1ACACNA2D1CACNA1B | |
| SCHEMBL4441719 | 0.74 | AKR1C3 (0.46) | CASRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |