Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446504 | 0.80 | MAOA (0.39) | SLC6A4SLC6A3SLC6A2PIM1PIM2 | |
| SCHEMBL4436040 | 0.77 | HSD11B1 (0.37) | SLC6A3KMT2A | |
| SCHEMBL4283467 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2NR1I2PIM1 | |
| SCHEMBL20886289 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2NR1I2PIM1 | |
| SCHEMBL10157208 | 0.76 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2NR1I2 | |
| SCHEMBL4438204 | 0.74 | CYP2A6 (0.34) | SLC6A3KMT2A | |
| SCHEMBL8535883 | 0.72 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2PIM1PIM2 | |
| SCHEMBL4554666 | 0.71 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2PIM1PIM2 | |
| SCHEMBL625374 | 0.70 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2PIM1PIM2 | |
| SCHEMBL19955250 | 0.69 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |