⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456748 | 0.82 | ADAMTS4 (0.30) | — | |
| SCHEMBL1232231 | 0.81 | — | — | |
| SCHEMBL8321058 | 0.73 | THRB (0.30) | — | |
| Lithium Ion SCHEMBL30093254 | 0.73 | THRB (0.30) | — | |
| SCHEMBL9217708 | 0.73 | THRB (0.30) | — | |
| SCHEMBL1155361 | 0.73 | THRB (0.30) | — | |
| SCHEMBL1155647 | 0.71 | — | — | |
| Zinc Ion SCHEMBL6829961 | 0.67 | P2RX4 (0.30) | — | |
| Lithium Ion SCHEMBL17924045 | 0.67 | — | — | |
| SCHEMBL6449267 | 0.66 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137184-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124323-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-16 | — | — | WO | disclosed |