Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645918 | 0.82 | PTPRC (0.52) | ALDH1A1POLBCES1MEN1KMT2A | |
| SCHEMBL1647740 | 0.78 | MAPK1 (0.55) | MAPK1ALDH1A1POLBHSD11B1CES1 | |
| SCHEMBL28551166 | 0.77 | HSD17B10 (0.54) | MAPK1ALDH1A1POLBHSD11B1CES1 | |
| SCHEMBL3406125 | 0.76 | MEN1 (0.45) | GSK3BMAPK1ALDH1A1POLBMEN1 | |
| SCHEMBL2230940 | 0.75 | GSK3B (0.53) | GSK3BMAPK1ALDH1A1POLBHSD11B1 | |
| SCHEMBL677959 | 0.74 | HSD17B10 (0.56) | MAPK1ALDH1A1POLBHSD11B1CES1 | |
| SCHEMBL5674580 | 0.74 | POLB (0.54) | MAPK1ALDH1A1POLBHSD11B1CES1 | |
| SCHEMBL8327387 | 0.74 | ALDH1A1 (0.47) | MAPK1ALDH1A1POLBHSD11B1CA1 | |
| SCHEMBL28677424 | 0.73 | GSK3B (0.48) | GSK3BALDH1A1POLBCES1CA1 | |
| SCHEMBL27579582 | 0.73 | HSD11B1 (0.54) | MAPK1ALDH1A1POLBHSD11B1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |