Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9351746 | 0.82 | TSHR (0.53) | KMT2AMEN1NPC1RAB9AMAPK1 | |
| SCHEMBL4780697 | 0.81 | MAPT (0.57) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL2988615 | 0.81 | MAPT (0.57) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL2984082 | 0.81 | MAPT (0.57) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL3026906 | 0.80 | MAPT (0.49) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL3010791 | 0.80 | MAPT (0.49) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL18668951 | 0.78 | MAPT (0.45) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL9247642 | 0.76 | CA12 (0.68) | MAPTKMT2AMEN1ADRB2ADRB1 | |
| SCHEMBL9498568 | 0.74 | ALDH1A1 (0.49) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22978547 | 0.74 | CES2 (0.50) | MAPTKMT2AMEN1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125702-A1 | LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE | Xenoport, Inc. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008076458-A1 | LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE | XENOPORT, INC. (US) | 2008-06-26 | — | — | WO | claimed |