SCHEMBL4440718

SCHEMBL4440718

CC(C)(C)c1cc(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2OP(O)F)c(OP(O)F)c(C(C)(C)C)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.33
HSPA5 P11021 2/20 0.33
CYP2C9 P11712 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
XBP1 P17861 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RXRA P19793 9/20 0.31
PPARG P37231 8/20 0.31
RARA P10276 3/20 0.31
RARB P10826 3/20 0.31
RXRB P28702 3/20 0.31
RXRG P48443 3/20 0.31
RARG P13631 3/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7651050 0.91 CYP2C19 (0.33) CYP2C19CYP2C9ALDH1A1GAAXBP1
SCHEMBL10413834 0.87 USP2 (0.34) SMN1; SMN2MAPK1CYP3A4
SCHEMBL9278608 0.87 CYP2C19 (0.35) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL5608285 0.86 CYP2C19 (0.34) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL9328498 0.84 ALDH1A1 (0.34) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL9356369 0.84 HSPA5 (0.51) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL5083123 0.84 ALDH1A1 (0.38) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL10415198 0.82 GABRA1 (0.32) RXRAPPARGRARARARBRXRB
SCHEMBL9355764 0.82 HSPA5 (0.54) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A
SCHEMBL7645310 0.81 RXRA (0.36) CYP2C19HSPA5CYP2C9SMN1; SMN2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0416321-B1 Crystalline polyolefin composition CHISSO CORP (JP) 1994-11-09 EP claimed
EP-0301355-B1 Aqueous aryl fluorophosphite suspension ETHYL CORP (US) 1993-12-29 EP claimed
US-5063264-A Molding materials CHISSO CORPORATION (JP) 1991-11-05 US claimed
US-4958034-A DISCOLORATION INHIBITION; REACTION OF OLEFIN AND MALEIC ANHYDRIDE IN ARYLFLUOROPHOSPHITE PRESENCE ETHYL CORPORATION (US) 1990-09-18 US claimed
US-4867907-A POLYMER STABILIZERS ETHYL CORPORATION (US) 1989-09-19 US claimed
EP-1384752-B1 INSULATED ELECTRIC WIRE YAZAKI CORP (JP) 2009-10-28 EP disclosed
US-6894227-B2 Insulated electric wire YAZAKI CORPORATION (JP) 2005-05-17 US disclosed
US-20040168820-A1 INSULATED ELECTRIC WIRE YAZAKI CORPORATION (JP) 2004-09-02 US disclosed
EP-1384752-A1 INSULATED ELECTRIC WIRE YAZAKI CORPORATION (JP) 2004-01-28 EP disclosed
EP-0622404-B1 Crystalline synthetic resin composition containing a group III or IV metal salt of a cyclic organophosphoric ester ASAHI DENKA KOGYO KK (JP) 1998-07-08 EP disclosed
EP-0658556-B1 Piperidine compound and stabilized polymeric material composition containing the same ASAHI DENKA KOGYO KK (JP) 1997-05-28 EP disclosed
US-5455347-A Di(2,2,6,6-tetramethylpiperidyl)-diaminotriazine derivatives as polymeric stabilizers giving heat, light and weather resistance ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1995-10-03 US disclosed
EP-0658556-A1 Piperidine compound and stabilized polymeric material composition containing the same ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1995-06-21 EP disclosed
EP-0416321-B1 Crystalline polyolefin composition CHISSO CORP (JP) 1994-11-09 EP disclosed
EP-0622404-A1 Crystalline synthetic resin composition containing a group III or IV metal salt of a cyclic organophosphoric ester ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1994-11-02 EP disclosed
US-5342868-A Containing alkali metal salt and polyvalent metal salt of a cyclic organophosphoric ester ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1994-08-30 US disclosed
EP-0301355-B1 Aqueous aryl fluorophosphite suspension ETHYL CORP (US) 1993-12-29 EP disclosed
US-5063264-A Molding materials CHISSO CORPORATION (JP) 1991-11-05 US disclosed
EP-0416321-A1 Crystalline polyolefin composition Chisso Corporation (JP) 1991-03-13 EP disclosed
US-4867907-A POLYMER STABILIZERS ETHYL CORPORATION (US) 1989-09-19 US disclosed