Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554357 | 0.79 | RORC (0.46) | HDAC1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13949529 | 0.76 | MEN1 (0.66) | HDAC1MEN1KMT2ALMNAMAPT | |
| SCHEMBL27783025 | 0.71 | MAPT (0.65) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL3329872 | 0.71 | MEN1 (0.49) | HDAC1MEN1KMT2ALMNAMAPT | |
| SCHEMBL16685574 | 0.71 | KMT2A (0.70) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL13300078 | 0.70 | LMNA (0.49) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL22724808 | 0.69 | MAPT (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL12443480 | 0.69 | MEN1 (1.00) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL31192562 | 0.69 | MAPT (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL1117871 | 0.67 | MAPT (0.67) | MEN1KMT2ALMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |