Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235288 | 0.80 | HPGD (0.62) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL4235282 | 0.78 | HPGD (0.58) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL7369653 | 0.77 | BRD4 (0.41) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL19747579 | 0.76 | HPGD (0.78) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL12821388 | 0.75 | HPGD (0.67) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL7651189 | 0.74 | HPGD (1.00) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL22972357 | 0.73 | HPGD (0.72) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL1201512 | 0.73 | LMNA (0.49) | HPGDALDH1A1KDM4ERCE1KMT2A | |
| SCHEMBL536590 | 0.73 | KDM4E (0.46) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1477696 | 0.73 | P2RX7 (0.45) | ALDH1A1KDM4EKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125753-A1 | FUSED HETEROCYCLIC COMPOUNDS HAVING CRF ANTAGONISTIC ACTIVITY | Takeda Pharmaceutical Company Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008082003-A1 | FUSED HETEROCYCLIC COMPOUNDS HAVING CRF ANTAGONISTIC ACTIVITY | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-10 | — | — | WO | disclosed |