Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334602 | 0.84 | NPC1 (0.67) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL9010386 | 0.74 | MEN1 (0.50) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL4441907 | 0.73 | THRA (0.43) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL10328621 | 0.73 | NPC1 (0.53) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL4447954 | 0.72 | THRA (0.40) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL988885 | 0.72 | NPC1 (0.55) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL8160885 | 0.71 | CYP2C19 (0.51) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL10328547 | 0.71 | NPC1 (0.51) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL9356623 | 0.71 | RAB9A (0.52) | NPC1CYP1A2CYP2C19RECQLRAB9A | |
| SCHEMBL10328616 | 0.71 | RXRA (0.52) | NPC1CYP1A2CYP2C19RECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120923-B1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | SANOFI SA (FR) | 2012-07-18 | — | — | EP | disclosed |
| EP-2120923-A1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008086949-A1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | WO | disclosed |