Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PPM1D | O15297 | 2/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10024054 | 1.00 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL2067039 | 1.00 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL9269812 | 1.00 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL10024025 | 1.00 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL4643619 | 1.00 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL22722148 | 0.89 | HMGCR (0.41) | HMGCRHDAC1HDAC2HDAC6PRKCA | |
| SCHEMBL10024055 | 0.87 | HMGCR (0.37) | HMGCRHDAC1HDAC2HDAC6PPM1D | |
| SCHEMBL2168815 | 0.85 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6PPM1D | |
| SCHEMBL2167968 | 0.85 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL4595118 | 0.85 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134696-A2 | PROCESSES FOR THE PREPARATION OF STATINS, PARTICULARLY ROSUVASTATIN, AND INTERMEDIATES FOR THE PREPARATION THEREOF | Lek Pharmaceuticals D.D. (SI) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008119810-A2 | PROCESSES FOR THE PREPARATION OF STATINS, PARTICULARLY ROSUVASTATIN, AND INTERMEDIATES FOR THE PREPARATION THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2008-10-09 | — | — | WO | disclosed |
| EP-1937696-A1 | PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS | LEK Pharmaceuticals D.D. (SI) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039287-A1 | PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS | LEK PHARMACEUTICALS D.D. (SI) | 2007-04-12 | — | — | WO | disclosed |