Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169371 | 1.00 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6BUB1 | |
| SCHEMBL2167968 | 1.00 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6BUB1 | |
| SCHEMBL10024055 | 0.87 | HMGCR (0.37) | HMGCRHDAC1HDAC2HDAC6BUB1 | |
| SCHEMBL2168815 | 0.85 | HMGCR (0.36) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL9269812 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL4643619 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL2067039 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL10024054 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL10024025 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A | |
| SCHEMBL4440967 | 0.85 | HMGCR (0.38) | HMGCRHDAC1HDAC2HDAC6TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604483-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1994-07-06 | — | — | EP | claimed |
| WO-1993006235-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1993-04-01 | — | — | WO | claimed |
| EP-1937696-A1 | PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS | LEK Pharmaceuticals D.D. (SI) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039287-A1 | PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS | LEK PHARMACEUTICALS D.D. (SI) | 2007-04-12 | — | — | WO | disclosed |
| EP-0604483-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006235-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |