Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LIG1 | P18858 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82156 | 0.78 | LATS1 (0.36) | PRKCQHDAC1LATS1CSNK1E | |
| SCHEMBL5226095 | 0.72 | ALDH1A1 (0.46) | KMT2AHDAC3HDAC2DAOPTGER1 | |
| SCHEMBL4438126 | 0.71 | DAO (0.44) | KMT2AL3MBTL1DAOPTGER1PKM | |
| SCHEMBL5228374 | 0.71 | KMT2A (0.49) | KMT2AL3MBTL1DAOPTGER1PKM | |
| SCHEMBL4441335 | 0.68 | CHRNA7 (0.45) | KMT2ADAOPKMLIG1 | |
| SCHEMBL4432653 | 0.68 | DAO (0.41) | GLAKMT2AL3MBTL1DAOPTGER1 | |
| SCHEMBL19035611 | 0.67 | HTR3E (0.52) | KMT2APRKCQHDAC1LATS1CSNK1E | |
| SCHEMBL6274318 | 0.67 | DAO (0.39) | KMT2AHDAC3HDAC2DAOPTGER1 | |
| SCHEMBL4554523 | 0.67 | CHKA (0.41) | KMT2ADAOPTGER1PKMLIG1 | |
| SCHEMBL18096106 | 0.67 | PRKCQ (0.42) | L3MBTL1PRKCQHDAC1LATS1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |