Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.57 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591304 | 0.87 | FLT3 (0.56) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4444458 | 0.86 | FLT3 (0.59) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967448 | 0.70 | FLT3 (0.61) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967147 | 0.70 | FLT3 (0.60) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967560 | 0.70 | YTHDC1 (0.71) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967790 | 0.70 | FLT3 (0.60) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17262750 | 0.70 | YTHDC1 (0.71) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967618 | 0.70 | FLT3 (0.60) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967885 | 0.70 | FLT3 (0.74) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17845526 | 0.69 | FLT3 (0.56) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | disclosed |
| EP-1656378-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY | IRM LLC (BM) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005016528-A2 | 6-SUBSTITUTED ANILINO PURINES AS RTK INHIBITORS | IRM LLC (BM) | 2005-02-24 | — | — | WO | disclosed |