Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 0.59 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591304 | 0.87 | FLT3 (0.56) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4442975 | 0.86 | FLT3 (0.57) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4432844 | 0.82 | FLT3 (0.60) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4444105 | 0.80 | FLT3 (0.63) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6015418 | 0.78 | FLT3 (0.37) | FLT3SRC | |
| SCHEMBL21967147 | 0.71 | FLT3 (0.60) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967400 | 0.70 | FLT3 (0.59) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967448 | 0.69 | FLT3 (0.61) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29659500 | 0.69 | NPC1 (0.58) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21967824 | 0.69 | FLT3 (0.58) | FLT3YTHDC1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | disclosed |
| EP-1656378-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY | IRM LLC (BM) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005016528-A2 | 6-SUBSTITUTED ANILINO PURINES AS RTK INHIBITORS | IRM LLC (BM) | 2005-02-24 | — | — | WO | disclosed |