Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438224 | 0.83 | SMN1; SMN2 (0.32) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL10236212 | 0.78 | SMN1; SMN2 (0.39) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL23811949 | 0.76 | SMN1; SMN2 (0.38) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL9074167 | 0.76 | SMN1; SMN2 (0.42) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL30843769 | 0.76 | SMN1; SMN2 (0.42) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL31497679 | 0.72 | SMN1; SMN2 (0.45) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL10279383 | 0.72 | CD44 (0.42) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL16736848 | 0.71 | ALOX15 (0.52) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL13911912 | 0.70 | ALDH1A1 (0.41) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A | |
| SCHEMBL12162725 | 0.69 | SMN1; SMN2 (0.44) | CYP2C9CYP2C19SMN1; SMN2TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124937-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |