Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148744 | 0.81 | KDM4E (0.62) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL860250 | 0.75 | CA12 (0.70) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL16601804 | 0.74 | KDM4E (0.51) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL12606551 | 0.73 | KDM4E (0.56) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL22018376 | 0.72 | MEN1 (0.55) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL13249175 | 0.72 | KMT2A (0.48) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL29322688 | 0.71 | KMT2A (0.60) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL444334 | 0.71 | PIN1 (0.88) | PIN1PIN4KMT2AMEN1ALDH1A1 | |
| SCHEMBL11947524 | 0.68 | ANPEP (0.50) | PIN1PIN4KMT2AKDM4EMEN1 | |
| SCHEMBL10062486 | 0.67 | TERT (0.61) | PIN1PIN4KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072814-A1 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9796784-B2 | Methods and compositions for the generation and use of conformation-specific antibodies | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20150038683-A1 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2015-02-05 | — | — | US | disclosed |
| US-20140242100-A1 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-8802439-B2 | Methods for enhancing infectivity of retroviruses | NATIONAL INSTITUTES OF HEALTH | 2014-08-12 | — | — | US | disclosed |
| US-8771693-B2 | Methods and compositions for the generation and use of conformation-specific antibodies | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| EP-2733213-A1 | Kit for producing a retrovirus with enhanced infectivity | Saphire, Andrew C. (US) | 2014-05-21 | — | — | EP | disclosed |
| US-20130028900-A1 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES | BETH ISRAEL DEACONESS MEDICAL CENTER INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-20120064604-A1 | METHODS FOR ENHANCING INFECTIVITY OF RETROVIRUSES | NATIONAL INSTITUTES OF HEALTH | 2012-03-15 | — | — | US | disclosed |