Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211332 | 0.82 | ALDH1A1 (0.55) | ALDH1A1GAASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL29956155 | 0.74 | SMN1; SMN2 (0.42) | ALDH1A1GAASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL1357311 | 0.74 | SMN1; SMN2 (0.42) | ALDH1A1GAASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL5961561 | 0.74 | PKM (0.46) | ALDH1A1GAASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL766122 | 0.74 | L3MBTL1 (0.58) | ALDH1A1GAASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL18770490 | 0.74 | ALB (0.32) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL17501932 | 0.72 | — | — | |
| SCHEMBL17295098 | 0.71 | ERN1 (0.35) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL17290359 | 0.71 | ERN1 (0.35) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL29052280 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409263-B | Substituted benzoyl compounds and application thereof | 东莞市东阳光农药研发有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-110903279-B | Pyrazole compound, salt and application thereof | 潍坊中农联合化工有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-111559965-B | Substituted benzoyl compounds and application thereof in agriculture | 东莞市东阳光农药研发有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-112409263-A | Substituted benzoyl compound and application thereof | 东莞市东阳光农药研发有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111670182-A | Quinoline derivatives, preparation method and application thereof | 东莞市东阳光农药研发有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-111559965-A | Substituted benzoyl compounds and application thereof in agriculture | 东莞市东阳光农药研发有限公司 | 2020-08-21 | — | — | CN | disclosed |
| CN-110903279-A | Pyrazole compound and salt and application thereof | 潍坊中农联合化工有限公司 | 2020-03-24 | — | — | CN | disclosed |
| US-9981901-B2 | IRE-1α inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2018-05-29 | — | — | US | disclosed |
| US-20170152206-A1 | IRE-1alpha INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2017-06-01 | — | — | US | disclosed |
| US-9546149-B2 | IRE-1α inhibitors | MANNKIND CORPORATION (US) | 2017-01-17 | — | — | US | disclosed |
| US-20160168116-A1 | IRE-1alpha Inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2016-06-16 | — | — | US | disclosed |
| US-9241942-B2 | IRE-1α inhibitors | MANNKIND CORPORATION (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140080832-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20110065162-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2011-03-17 | — | — | US | disclosed |
| US-7858666-B2 | inositol requiring enzyme 1 (IRE-1 alpha) inhibitors such as 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde, relieve protein folding stress by enhancing molecular chaperone activity and protects cells from stress induced apoptosis; autoimmune diseases; anticancer; viricides | MANNKIND CORPORATION (US) | 2010-12-28 | — | — | US | disclosed |
| EP-1789401-B1 | ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| EP-1426365-B9 | 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME | MITSUI CHEMICALS AGRO INC (JP) | 2009-10-21 | — | — | EP | disclosed |
| US-20090186893-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2009-07-23 | — | — | US | disclosed |
| EP-1426365-B1 | 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME | SANKYO AGRO CO LTD (JP) | 2009-07-15 | — | — | EP | disclosed |
| CN-1543455-A | 3-phenoxy-4-pyridazinol derivatives and herbicidal compositions containing the same | 三共农业株式会社 | 2004-11-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152206-A1 | IRE-1alpha INHIBITORS | XBP1, DDIT3, ERN1 | ALDH1A1 2586/4885GAA 704/4885SMN1; SMN2 1384/4885 |
| US-20160168116-A1 | IRE-1alpha Inhibitors | XBP1, DDIT3, ERN1 | ALDH1A1 2586/4885GAA 704/4885SMN1; SMN2 1384/4885 |
| US-20140080832-A1 | IRE-1alpha INHIBITORS | XBP1, DDIT3, ERN1 | ALDH1A1 2586/4885GAA 704/4885SMN1; SMN2 1384/4885 |
| US-20090186893-A1 | IRE-1alpha INHIBITORS | XBP1, DDIT3, ERN1 | ALDH1A1 2586/4885GAA 704/4885SMN1; SMN2 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.