Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6567422 | 0.92 | ESR2 (0.35) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| Hydrochloric Acid SCHEMBL27629774 | 0.74 | ESR2 (0.41) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| SCHEMBL4830408 | 0.71 | ESR2 (0.60) | ESR2CYP2A6CYP2B6BACE1PDCD1 | |
| SCHEMBL1476609 | 0.71 | ALDH1A1 (0.58) | CYP2A6PTGS2BACE1PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL27629776 | 0.71 | ESR2 (0.41) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| Hydrochloric Acid SCHEMBL714599 | 0.70 | ESR2 (0.38) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| Hydrochloric Acid SCHEMBL722083 | 0.70 | ESR2 (0.38) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| Hydrochloric Acid SCHEMBL4444069 | 0.69 | ESR2 (0.40) | ESR2CYP2A6CYP2B6PTGS2BACE1 | |
| SCHEMBL6825024 | 0.69 | BACE1 (0.52) | CYP2A6PTGS2BACE1ALDH1A1HSD17B10 | |
| SCHEMBL27620844 | 0.69 | ALDH1A1 (0.50) | CYP2A6CYP2B6PTGS2BACE1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1247573-B1 | Catalyst for polymerizing olefin and process for polymerizing olefin | JAPAN POLYPROPYLENE CORP (JP) | 2009-10-21 | — | — | EP | disclosed |
| US-7005400-B2 | Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin | JAPAN POLYCHEM CORPORATION (JP) | 2006-02-28 | — | — | US | disclosed |
| US-20030054952-A1 | Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin | JAPAN POLYCHEM CORPORATION (JP) | 2003-03-20 | — | — | US | disclosed |
| EP-1247573-A1 | Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin | Japan Polychem Corporation, Catalyst Research & Development Center (JP) | 2002-10-09 | — | — | EP | disclosed |