Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4444061 | 0.92 | ESR2 (0.40) | ESR2CYP2A6CYP2B6PTGS2SQOR | |
| Hydrochloric Acid SCHEMBL6869685 | 0.74 | ESR2 (0.35) | ESR2CYP2A6CYP2B6PTGS2PDCD1 | |
| Hydrochloric Acid SCHEMBL27629774 | 0.68 | ESR2 (0.41) | ESR2CYP2A6CYP2B6PTGS2PDCD1 | |
| SCHEMBL4830408 | 0.65 | ESR2 (0.60) | ESR2CYP2A6CYP2B6SQORPDCD1 | |
| SCHEMBL1476609 | 0.65 | ALDH1A1 (0.58) | CYP2A6PTGS2PDCD1CD274ALDH1A1 | |
| Hydrochloric Acid SCHEMBL722083 | 0.65 | ESR2 (0.38) | ESR2CYP2A6CYP2B6PTGS2PDCD1 | |
| Hydrochloric Acid SCHEMBL714599 | 0.65 | ESR2 (0.38) | ESR2CYP2A6CYP2B6PTGS2PDCD1 | |
| Hydrochloric Acid SCHEMBL4444069 | 0.63 | ESR2 (0.40) | ESR2CYP2A6CYP2B6PTGS2PDCD1 | |
| SCHEMBL6825024 | 0.63 | BACE1 (0.52) | CYP2A6PTGS2ALDH1A1LMNAMEN1 | |
| SCHEMBL27620844 | 0.63 | ALDH1A1 (0.50) | CYP2A6CYP2B6PTGS2PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0962474-B1 | Propylene block copolymer and resin composition | JAPAN POLYCHEM CORP (JP) | 2004-04-07 | — | — | EP | disclosed |
| US-6469100-B2 | COORDINATION CATALYST | JAPAN POLYCHEM CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| US-20010014719-A1 | PROPYLENE BLOCK COPOLYMER AND RESIN COMPOSITION | JAPAN POLYCHEM CORPORATION (JP) | 2001-08-16 | — | — | US | disclosed |
| EP-0962474-A1 | Propylene block copolymer and resin composition | Japan Polychem Corporation (JP) | 1999-12-08 | — | — | EP | disclosed |