Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245271 | 0.80 | POLB (0.46) | POLBL3MBTL1FFAR1ACEREN | |
| SCHEMBL28245274 | 0.80 | POLB (0.46) | POLBL3MBTL1FFAR1ACEREN | |
| SCHEMBL1777983 | 0.80 | POLB (0.48) | POLBL3MBTL1FFAR1ACEREN | |
| SCHEMBL4066863 | 0.80 | POLB (0.48) | POLBL3MBTL1FFAR1ACEREN | |
| SCHEMBL1777982 | 0.80 | POLB (0.48) | POLBL3MBTL1FFAR1ACEREN | |
| SCHEMBL7454324 | 0.79 | POLB (0.39) | POLBL3MBTL1HRH3LMNA | |
| SCHEMBL5412325 | 0.79 | OPRK1 (0.46) | DPP4POLBL3MBTL1PREPFAP | |
| SCHEMBL5015466 | 0.79 | CHRNB2 (0.41) | DPP4 | |
| SCHEMBL3295966 | 0.79 | OPRK1 (0.46) | DPP4POLBL3MBTL1PREPFAP | |
| SCHEMBL5412332 | 0.79 | OPRK1 (0.46) | DPP4POLBL3MBTL1PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134343-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008124849-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |