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Sugi Predict / Compounds / SCHEMBL4444218

SCHEMBL4444218

SCHEMBL4444218

CC(CO)OC(=O)O[C@]1(C(=O)O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 2/20 0.61
▸ SMN1; SMN2 Q16637 7/20 0.56
▸ LMNA P02545 5/20 0.56
▸ NR3C1 P04150 4/20 0.56
▸ MAPT P10636 4/20 0.56
▸ HIF1A Q16665 3/20 0.56
▸ PGR P06401 3/20 0.56
▸ CYP3A4 P08684 3/20 0.56
▸ MEN1 O00255 3/20 0.56
▸ KMT2A Q03164 3/20 0.56
▸ ADORA3 P0DMS8 2/20 0.56
▸ SLC6A3 Q01959 2/20 0.56
▸ HPGD P15428 1/20 0.56
▸ MLNR O43193 1/20 0.56
▸ NR1I2 O75469 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ PDE4D Q08499 1/20 0.56
▸ PDE3A Q14432 1/20 0.56
▸ NPSR1 Q6W5P4 1/20 0.56
▸ SHBG P04278 5/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4443905 0.86 AR (0.59) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL5697436 0.85 AR (0.63) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL4441997 0.83 LMNA (0.55) LMNANR3C1MAPTHIF1APGR
SCHEMBL10598126 0.83 SHBG (0.67) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL10598120 0.83 SHBG (0.67) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL4451873 0.82 AR (0.59) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL5697445 0.81 AR (0.60) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL10385090 0.81 AR (0.65) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL7209282 0.81 SHBG (0.65) ARSMN1; SMN2LMNANR3C1MAPT
SCHEMBL10383760 0.79 AR (0.65) ARSMN1; SMN2LMNANR3C1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2026818-A2 COMBINATION OF ANTI-INFLAMMATORY STEROIDS HAVING TRANSPORTER-ENHANCED CORTICOSTEROID ACTIVITY Bodor, Nicholas S. (US) 2009-02-25 — — EP claimed
WO-2007142842-A2 COMBINATION OF ANTI-INFLAMMATORY STEROIDS HAVING TRANSPORTER-ENHANCED CORTICOSTEROID ACTIVITY BODOR NICHOLAS S (US) 2007-12-13 — — WO claimed
EP-1653974-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SOFT ANTI-INFLAMMATORY STEROIDS FOR TOPICAL OR OTHER LOCAL APPLICATION BODOR, Nicholas S. (US) 2006-05-10 — — EP claimed
WO-2005000317-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SOFT ANTI-INFLAMMATORY STEROIDS FOR TOPICAL OR OTHER LOCAL APPLICATION BODOR NICHOLAS S (US) 2005-01-06 — — WO claimed
EP-2026818-A2 COMBINATION OF ANTI-INFLAMMATORY STEROIDS HAVING TRANSPORTER-ENHANCED CORTICOSTEROID ACTIVITY Bodor, Nicholas S. (US) 2009-02-25 — — EP disclosed
WO-2007142842-A2 COMBINATION OF ANTI-INFLAMMATORY STEROIDS HAVING TRANSPORTER-ENHANCED CORTICOSTEROID ACTIVITY BODOR NICHOLAS S (US) 2007-12-13 — — WO disclosed
EP-1658083-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SELECTED ANTI-INFLAMMATORY STEROIDS BODOR, Nicholas S. (US) 2006-05-24 — — EP disclosed
EP-1653974-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SOFT ANTI-INFLAMMATORY STEROIDS FOR TOPICAL OR OTHER LOCAL APPLICATION BODOR, Nicholas S. (US) 2006-05-10 — — EP disclosed
WO-2005000317-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SOFT ANTI-INFLAMMATORY STEROIDS FOR TOPICAL OR OTHER LOCAL APPLICATION BODOR NICHOLAS S (US) 2005-01-06 — — WO disclosed
WO-2004112800-A1 ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SELECTED ANTI-INFLAMMATORY STEROIDS BODOR NICHOLAS S (US) 2004-12-29 — — WO disclosed