SCHEMBL4444307

SCHEMBL4444307

O=C1NCCN1c1ccc(Cl)c(-c2cccc(OCc3ccccc3)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.51
BRD4 O60885 2/20 0.44
CREBBP Q92793 1/20 0.44
GRM5 P41594 1/20 0.44
ABL1 P00519 1/20 0.43
SRC P12931 1/20 0.43
MAOB P27338 1/20 0.42
PRKDC P78527 2/20 0.42
SNRNP200 O75643 1/20 0.42
PLAT P00750 1/20 0.42
ATM Q13315 1/20 0.42
BACE1 P56817 1/20 0.42
DDB1 Q16531 1/20 0.41
CRBN Q96SW2 1/20 0.41
GSTP1 P09211 1/20 0.40
IGF1R P08069 1/20 0.40
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
XBP1 P17861 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4434062 0.86 ALOX5 (0.46) ALOX5BRD4CREBBPGRM5MAOB
SCHEMBL22750386 0.84 ALOX5 (0.67) ALOX5GRM5ABL1MAOBSNRNP200
SCHEMBL29508690 0.84 ALOX5 (0.67) ALOX5GRM5ABL1MAOBSNRNP200
SCHEMBL14280129 0.77 ALOX5 (0.53) ALOX5MAOBDDB1CRBNGSTP1
SCHEMBL3977885 0.72 ALOX5 (0.59) ALOX5GRM5MAOBSNRNP200ALDH1A1
SCHEMBL8915218 0.71 FFAR4 (0.46) ALOX5BRD4
SCHEMBL2300172 0.71 MAPT (0.39) KMT2ANPSR1
Hydrochloric Acid SCHEMBL6469932 0.71 BACE1 (0.46) ALOX5BRD4CREBBPGRM5MAOB
SCHEMBL2302364 0.70 USP2 (0.36) ALOX5MAOBGSTP1ALDH1A1HPGD
SCHEMBL4441322 0.69 KMT2A (0.43) BRD4ALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121598-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2009-11-25 EP claimed
WO-2008076754-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2008-06-26 WO claimed
EP-2121598-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2009-11-25 EP disclosed
WO-2008076754-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY IRM LLC (BM) 2008-06-26 WO disclosed