Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047724 | 0.87 | DRD2 (0.46) | TP53HTTKCNH2CHEK1KDM4E | |
| SCHEMBL4755013 | 0.81 | PARP1 (0.44) | TP53HTTCHEK1KDM4EHSD17B10 | |
| SCHEMBL3359340 | 0.77 | KCNH2 (0.62) | KCNH2KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3355445 | 0.77 | KCNH2 (0.62) | KCNH2KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3359338 | 0.77 | KCNH2 (0.62) | KCNH2KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL4441167 | 0.77 | PARP1 (0.44) | TP53HTTCHEK1KDM4EHSD17B10 | |
| SCHEMBL3846224 | 0.76 | PARP1 (0.46) | KCNH2CHEK1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL3353344 | 0.71 | KCNH2 (0.48) | KCNH2KDM4E | |
| SCHEMBL5048771 | 0.71 | KCNH2 (0.46) | KCNH2DRD2DRD3PARP1 | |
| SCHEMBL4438705 | 0.70 | PARP1 (0.41) | TP53HTTCHEK1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121702-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008071961-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |