Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436875 | 0.85 | ALK (0.33) | PARP1HSD17B10TSHRHTT | |
| SCHEMBL4755013 | 0.77 | PARP1 (0.44) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL3846224 | 0.74 | PARP1 (0.46) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL4441167 | 0.73 | PARP1 (0.44) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL4444391 | 0.70 | TP53 (0.40) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL5047724 | 0.69 | DRD2 (0.46) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL3716513 | 0.64 | IDH1 (0.50) | PARP1IDH1KDM4EHSD17B10TSHR | |
| SCHEMBL3709499 | 0.63 | IDH1 (0.49) | IDH1KDM4EHSD17B10TSHRALDH1A1 | |
| SCHEMBL1080585 | 0.60 | NOS3 (0.51) | IDH1DRD2DRD4DRD3 | |
| SCHEMBL3396789 | 0.60 | DAO (0.63) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121702-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008071961-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |