SCHEMBL4444396

SCHEMBL4444396

Cc1nc2c(N)nc(NC3CCOCC3)nc2n1-c1cscn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.38
ADORA2A P29274 2/20 0.36
MAPK10 P53779 3/20 0.35
MAPK8 P45983 2/20 0.35
MAPK9 P45984 2/20 0.35
HRH4 Q9H3N8 1/20 0.34
P2RX3 P56373 1/20 0.34
P2RX2 Q9UBL9 1/20 0.34
PIK3CD O00329 2/20 0.34
PIK3CA P42336 1/20 0.34
PIK3CB P42338 1/20 0.34
MTOR P42345 1/20 0.34
PIK3CG P48736 1/20 0.34
MKNK1 Q9BUB5 1/20 0.33
MKNK2 Q9HBH9 1/20 0.33
SRC P12931 1/20 0.33
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3591201 0.71 PDE8A (0.35) PIK3CA
SCHEMBL3597600 0.68 PIK3R2 (0.34)
SCHEMBL2303826 0.62 MAPK1 (0.46) MAPK1MAPK10MAPK8MAPK9HRH4
SCHEMBL11488384 0.60 ADORA2A (0.60) ADORA2ASRCPDGFRAFLT3
SCHEMBL30784995 0.60 MAPK1 (0.53) MAPK1HRH4PIK3CDPIK3CAPIK3CB
SCHEMBL29842140 0.58 CDK2 (0.54) MAPK1MAPK10MAPK8MAPK9P2RX3
SCHEMBL19144932 0.58 MAPK1 (1.00) MAPK1MAPK10MAPK8MAPK9HDAC3
SCHEMBL15830033 0.56 MAPK1 (0.62) MAPK1MAPK10MAPK8MAPK9HRH4
SCHEMBL10188247 0.56 MAPK1 (0.62) MAPK1MAPK10HRH4PIK3CDMKNK1
SCHEMBL5447194 0.56 MAPK1 (0.49) MAPK1MAPK10MAPK8MAPK9HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1656378-A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY IRM LLC (BM) 2006-05-17 EP claimed
WO-2005016528-A2 6-SUBSTITUTED ANILINO PURINES AS RTK INHIBITORS IRM LLC (BM) 2005-02-24 WO claimed
EP-2124954-A2 PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES IRM LLC (BM) 2009-12-02 EP disclosed
WO-2008094737-A2 PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES IRM LLC (BM) 2008-08-07 WO disclosed