Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.72 |
| ▸ | DRD2 | P14416 | 3/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.65 |
| ▸ | DRD3 | P35462 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674000 | 0.90 | CHRM1 (0.69) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL1271627 | 0.88 | OPRL1 (0.70) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL26666399 | 0.86 | DRD2 (0.70) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL10316252 | 0.84 | DRD2 (0.76) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL4444715 | 0.84 | CHRM1 (0.69) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL4403836 | 0.83 | DRD2 (0.72) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL28979863 | 0.82 | DRD2 (0.65) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL11594590 | 0.81 | OPRM1 (0.61) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL11595640 | 0.81 | CHRM1 (0.59) | CHRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL29364904 | 0.81 | DRD2 (0.64) | CHRM1DRD2HTR1AADRA2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124883-A1 | NOVEL 1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009124883-A1 | NOVEL 1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-10-15 | — | — | WO | disclosed |