Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 6/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.56 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.51 |
| ▸ | MMP14 | P50281 | 3/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450456 | 0.89 | NPC1 (0.64) | S1PR3S1PR4TACR3ALDH1A1CA1 | |
| SCHEMBL4443040 | 0.89 | S1PR3 (0.53) | S1PR3S1PR4TACR3ALDH1A1CYP1A2 | |
| SCHEMBL4443050 | 0.85 | ALDH1A1 (0.51) | S1PR3S1PR4TACR3ALDH1A1LMNA | |
| SCHEMBL4443046 | 0.85 | ALDH1A1 (0.51) | S1PR3S1PR4TACR3ALDH1A1LMNA | |
| SCHEMBL4448206 | 0.82 | MTTP (0.52) | S1PR3TACR3LMNAMMP1MMP2 | |
| SCHEMBL4448204 | 0.82 | MTTP (0.52) | S1PR3TACR3LMNAMMP1MMP2 | |
| SCHEMBL13956904 | 0.82 | MMP1 (0.54) | TACR3LMNAMMP1MMP2MMP3 | |
| SCHEMBL13686129 | 0.82 | MMP1 (0.54) | TACR3LMNAMMP1MMP2MMP3 | |
| SCHEMBL13649413 | 0.82 | MMP1 (0.54) | TACR3LMNAMMP1MMP2MMP3 | |
| SCHEMBL9848833 | 0.82 | ALDH1A1 (0.55) | S1PR3S1PR4TACR3ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| WO-2008141446-A1 | AMINO ACID DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | CACNA1G, CACNA1H, CACNA1I | S1PR3 4723/4885S1PR4 4651/4885TACR3 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.