Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 10/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 10/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440298 | 0.92 | OPRM1 (0.41) | OPRM1HSD11B1PLD2PLD1PGR | |
| SCHEMBL4437945 | 0.92 | OPRM1 (0.42) | OPRM1HSD11B1PLD2PLD1PGR | |
| SCHEMBL5000823 | 0.89 | PLD2 (0.42) | OPRM1HSD11B1PLD2PLD1KCNH2 | |
| SCHEMBL4440308 | 0.89 | ADRB2 (0.43) | OPRM1HSD11B1PLD2PLD1CHRM2 | |
| SCHEMBL4435839 | 0.89 | PLD2 (0.42) | OPRM1HSD11B1PLD2PLD1KCNH2 | |
| SCHEMBL5006625 | 0.88 | PLD2 (0.42) | OPRM1HSD11B1PLD2PLD1KCNH2 | |
| SCHEMBL4446718 | 0.86 | OPRM1 (0.42) | OPRM1HSD11B1PLD2PLD1CHRM2 | |
| SCHEMBL4439024 | 0.85 | OPRM1 (0.41) | OPRM1HSD11B1PLD2PLD1PGR | |
| SCHEMBL4440328 | 0.83 | OPRM1 (0.41) | OPRM1HSD11B1PLD2PLD1PGR | |
| SCHEMBL4435268 | 0.80 | PLD2 (0.43) | OPRM1HSD11B1PLD2PLD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |