SCHEMBL444506

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL443905	0.86	HDAC8 (0.56)	HDAC8LMNAPOLBGAAMAPT
	SCHEMBL447087	0.85	HTR1A (0.38)	HDAC8MAPTALOX15HDAC6
	SCHEMBL445296	0.84	HDAC8 (0.50)	HDAC8GAAMAPTALDH1A1CYP3A4
	SCHEMBL444654	0.77	HTR1A (0.39)	MAPTALOX15
	SCHEMBL445407	0.76	HDAC8 (0.50)	HDAC8GAAHDAC6
	SCHEMBL444145	0.76	HDAC8 (0.59)	HDAC8LMNAGAAALDH1A1HDAC6
	SCHEMBL442641	0.74	HDAC8 (0.52)	HDAC8MEN1KMT2AHDAC6HTT
	SCHEMBL442976	0.70	HDAC8 (0.53)	HDAC8HDAC6
	SCHEMBL444505	0.70	HDAC8 (1.00)	HDAC8HDAC6
	SCHEMBL444360	0.69	HDAC8 (0.58)	HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.