SCHEMBL445296

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL447087	0.89	HTR1A (0.38)	HDAC8HDAC6HTR1ADRD2MAPT
	SCHEMBL443072	0.88	HDAC8 (0.51)	HDAC8HDAC6HTR1ADRD2ADRB1
	SCHEMBL444506	0.84	HDAC8 (0.53)	HDAC8HDAC6ALDH1A1GAAMAPT
	SCHEMBL443814	0.80	HDAC8 (0.59)	HDAC8HDAC6
	SCHEMBL445407	0.79	HDAC8 (0.50)	HDAC8HDAC6HTR1ADRD2GAA
	SCHEMBL444145	0.79	HDAC8 (0.59)	HDAC8HDAC6HTR1ADRD2ALDH1A1
	SCHEMBL444654	0.78	HTR1A (0.39)	HTR1ADRD2ADRB1ADRB3MAPT
	SCHEMBL447624	0.78	HDAC8 (0.60)	HDAC8
	SCHEMBL442641	0.77	HDAC8 (0.52)	HDAC8HDAC6HTR1ADRD2MEN1
	SCHEMBL443994	0.77	HDAC8 (0.57)	HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.