Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440513 | 0.84 | SMYD3 (0.47) | SMYD3HSD11B1CTSCOPRL1PLD1 | |
| SCHEMBL10063156 | 0.79 | OPRM1 (0.40) | CTSCOPRM1OPRK1OPRL1 | |
| SCHEMBL4716706 | 0.79 | NOTUM (0.56) | CTSCOPRM1OPRK1OPRL1 | |
| SCHEMBL29567794 | 0.75 | SMYD3 (0.40) | SMYD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL29809539 | 0.75 | OPRM1 (0.61) | OPRM1OPRK1OPRL1 | |
| SCHEMBL828730 | 0.75 | OPRM1 (0.61) | OPRM1OPRK1OPRL1 | |
| Ammonia Solution, Strong SCHEMBL1764239 | 0.74 | OPRM1 (0.59) | OPRM1OPRK1OPRL1 | |
| SCHEMBL19691218 | 0.73 | ALDH1A1 (0.44) | SMYD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL30364090 | 0.73 | ALDH1A1 (0.44) | SMYD3PARP1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL3660693 | 0.72 | SMYD3 (0.59) | SMYD3KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107072205-A | SMYD inhibitors | EPIZYME股份有限公司 | 2017-08-18 | — | — | CN | disclosed |
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |