Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478104 | 0.73 | CYP3A4 (0.42) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL5742710 | 0.73 | AKR1C2 (0.57) | MAPTL3MBTL1LMNATDP1KDM4E | |
| SCHEMBL31337559 | 0.73 | AKR1C2 (0.57) | MAPTL3MBTL1LMNATDP1KDM4E | |
| SCHEMBL17694470 | 0.71 | PTGS1 (0.40) | L3MBTL1HTTTSPO | |
| SCHEMBL31618779 | 0.71 | POLB (0.42) | L3MBTL1SMN1; SMN2TSPOIDH1 | |
| SCHEMBL17385731 | 0.71 | HSP90AB1 (0.55) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL290340 | 0.70 | CES2 (0.46) | MAPTHTTCES2CES1CA1 | |
| SCHEMBL28052843 | 0.70 | CES2 (0.50) | NPC1RAB9AMAPTLMNACES2 | |
| SCHEMBL4422487 | 0.70 | NPC1 (0.56) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL11763680 | 0.69 | HTT (0.45) | L3MBTL1HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074102-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008043567-A1 | 2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2008-04-17 | — | — | WO | disclosed |