SCHEMBL290340

SCHEMBL290340

COc1ccc(C(=C=O)CN(C)C)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.46
CES1 P23141 2/20 0.46
CA1 P00915 5/20 0.44
CA2 P00918 5/20 0.44
GSK3B P49841 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
MEN1 O00255 1/20 0.43
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5776317 0.83 ALDH1A1 (0.49) HTTKMT2APARP10ALDH1A1MAPT
SCHEMBL5666967 0.81 SLC6A4 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL5567586 0.81 SMN1; SMN2 (0.41) MAOAMAOBMEN1KMT2AALDH1A1
SCHEMBL3411071 0.79 BCL2L1 (0.42) CES2CES1GSK3BMAOAMAOB
SCHEMBL3712653 0.77 HDAC3 (0.61) CES2CES1CA1CA2GSK3B
SCHEMBL16964474 0.76 TAS1R3 (0.43) MEN1HTTKMT2AALDH1A1HPGD
SCHEMBL28052843 0.76 CES2 (0.50) CES2CES1CA1CA2GSK3B
SCHEMBL16964035 0.75 TAS1R3 (0.43) MEN1CYP2D6HTTKMT2AALDH1A1
SCHEMBL16963959 0.75 ALDH1A1 (0.54) MEN1CYP2D6HTTKMT2AALDH1A1
SCHEMBL5774143 0.75 HTT (0.40) MEN1CYP2D6HTTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427057-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS Sloan-Kettering Institute for Cancer Research (US) 2012-03-14 EP disclosed
WO-2010129049-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2010-11-11 WO disclosed
EP-1648875-A1 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS Cyclacel Limited (GB) 2006-04-26 EP disclosed
WO-2005012262-A1 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS CYCLACEL LIMITED (GB) 2005-02-10 WO disclosed