Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 8/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452378 | 0.93 | ESR1 (0.45) | ALDH1A1GAAERAP1ESR1ESR2 | |
| SCHEMBL4454109 | 0.87 | HSD17B3 (0.40) | ALDH1A1GAAESR1ESR2ALOX15 | |
| SCHEMBL3186826 | 0.80 | PTPN1 (0.37) | ALDH1A1GAAERAP1TYRESR1 | |
| SCHEMBL4450682 | 0.78 | ESR2 (0.45) | ALDH1A1GAAESR1ESR2MAPT | |
| SCHEMBL4448363 | 0.76 | ESR1 (0.37) | ALDH1A1ESR1ESR2MAPTESRRB | |
| SCHEMBL4449859 | 0.75 | ESR2 (0.36) | ALDH1A1ESR1ESR2MAPTESRRB | |
| SCHEMBL4452367 | 0.74 | CYP3A4 (0.40) | ALDH1A1GAAESR1ESR2ALOX15 | |
| SCHEMBL6436723 | 0.73 | MPO (0.36) | ALDH1A1GAAALOX15MEN1KMT2A | |
| SCHEMBL13960113 | 0.72 | ESR1 (0.36) | ALDH1A1GAAESR1ESR2ALOX15 | |
| SCHEMBL14105587 | 0.72 | ESRRB (0.37) | ALDH1A1ESR1ESR2MAPTESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-08 | — | — | US | claimed |
| EP-1453820-B1 | SUBSTITUTED 6H-DIBENZO[C,H]CHROMENES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2005-06-01 | — | — | EP | claimed |
| US-6723747-B2 | ESTROGEN RECEPTOR MODULATORS USEFUL IN TREATING OR INHIBITING CONDITIONS, DISORDERS, OR DISEASE STATES AT LEAST PARTIALLY MEDIATED BY ESTROGEN DEFICIENCY OR EXCESS, OR WHICH MAY BE TREATED OR INHIBITED THROUGH USE OF ESTROGENIC AGENT | WYETH | 2004-04-20 | — | — | US | claimed |
| US-20030176491-A1 | Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents | WYETH | 2003-09-18 | — | — | US | claimed |
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| EP-1453820-B1 | SUBSTITUTED 6H-DIBENZO[C,H]CHROMENES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2005-06-01 | — | — | EP | disclosed |
| US-6723747-B2 | ESTROGEN RECEPTOR MODULATORS USEFUL IN TREATING OR INHIBITING CONDITIONS, DISORDERS, OR DISEASE STATES AT LEAST PARTIALLY MEDIATED BY ESTROGEN DEFICIENCY OR EXCESS, OR WHICH MAY BE TREATED OR INHIBITED THROUGH USE OF ESTROGENIC AGENT | WYETH | 2004-04-20 | — | — | US | disclosed |
| US-20030176491-A1 | Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents | WYETH | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176491-A1 | Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents | ESR2, ESR1, ESRRA | ALDH1A1 796/4885GAA 4426/4885ERAP1 2487/4885 |
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | COL2A1, COL1A1, COL14A1 | ALDH1A1 1461/4885GAA 1432/4885ERAP1 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.