Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782117 | 1.00 | TSHR (0.43) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL4447204 | 1.00 | TSHR (0.43) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL13863985 | 1.00 | TSHR (0.43) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL4447205 | 1.00 | TSHR (0.43) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL15093177 | 0.98 | TSHR (0.39) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL7033921 | 0.98 | TSHR (0.39) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL814218 | 0.91 | — | — | |
| SCHEMBL28596274 | 0.91 | TSHR (0.45) | TSHRPOLBALOX5 | |
| SCHEMBL27692179 | 0.84 | TSHR (0.34) | TSHRALDH1A1SPHK1SPHK2EPHX1 | |
| SCHEMBL28055784 | 0.84 | TSHR (0.34) | TSHRALDH1A1SPHK1SPHK2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404872-B2 | Production of 2,5-dihydrofurans and analogous compounds | CORNELL UNIVERSITY (US) | 2013-03-26 | — | — | US | disclosed |
| CN-101448807-B | Production of 2,5-dihydrofurans and analogous compounds | CORNELL RES FOUNDATION INC | 2013-02-06 | — | — | CN | disclosed |
| CN-101448807-A | Production of 2,5-dihydrofurans and analogous compounds | CORNELL RES FOUNDATION INC (US) | 2009-06-03 | — | — | CN | disclosed |
| US-20090131691-A1 | Production of 2,5-Dihydrofurans and Analogous Compounds | CORNELL RESEARCH FOUNDATION INC. (US) | 2009-05-21 | — | — | US | disclosed |
| WO-2007108999-A2 | PRODUCTION OF 2,5-DIHYDROFURANS AND ANALOGOUS COMPOUNDS | CORNELL UNIVERSITY (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131691-A1 | Production of 2,5-Dihydrofurans and Analogous Compounds | DHPS, DHFR, DHODH | TSHR 2635/4885ALDH1A1 87/4885SPHK1 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.