SCHEMBL4447494

SCHEMBL4447494

COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc(C#N)c1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 7/20 0.55
CYP1A2 P05177 6/20 0.55
CYP3A4 P08684 6/20 0.55
CYP2C19 P33261 6/20 0.55
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
LMNA P02545 3/20 0.55
CYP2D6 P10635 3/20 0.55
TSHR P16473 2/20 0.55
NFKB1 P19838 2/20 0.55
THPO P40225 2/20 0.55
MAPT P10636 2/20 0.55
KDM4E B2RXH2 3/20 0.50
ABCB11 O95342 3/20 0.50
NR1I2 O75469 3/20 0.50
NR3C1 P04150 3/20 0.50
ADORA3 P0DMS8 3/20 0.50
TBXA2R P21731 3/20 0.50
PDE4D Q08499 3/20 0.50
SCN5A Q14524 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8509173 1.00 CYP2C9 (0.55) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL30192384 1.00 CYP2C9 (0.55) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL8021648 0.93 CYP2C9 (0.56) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL8091053 0.91 NR3C2 (0.48) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL6947811 0.90 CYP1A2 (0.56) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL8912184 0.90 NR3C2 (0.47) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL6951166 0.89 CYP2C9 (0.53) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL6952048 0.89 CYP2C9 (0.55) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL7410229 0.87 CYP2C9 (0.66) CYP2C9CYP1A2CYP3A4CYP2C19MEN1
SCHEMBL9153822 0.86 CYP2C9 (0.58) CYP2C9CYP1A2CYP3A4CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090156639-A1 COMPOSITIONS AND METHODS OF TREATMENT USING L-TYPE CALCIUM CHANNEL BLOCKERS AND CHOLINESTERASE INHIBITORS TRIPPODI-MURPHY CRISTA 2009-06-18 US claimed
US-20090069361-A1 METHODS OF TREATMENT USING (+)- ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1, 4-DIHYDRO-2, 6-DIMETHYL-PYRIDINE-3, 5-DICARBOXYLATE MEMORY PHARMACEUTICALS CORPORATION (US) 2009-03-12 US claimed
EP-1952824-A1 Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors Memory Pharmaceuticals Corporation (US) 2008-08-06 EP claimed
EP-1684806-B1 COMPOSITIONS COMPRISING L-TYPE CALCIUM CHANNEL BLOCKERS AND CHOLINESTERASE INHIBITORS MEMORY PHARM CORP (US) 2008-06-25 EP claimed
US-20080026081-A1 Methods of Treatment Using (+)-Isopropyl 2-Ethoxyethyl-4-(2-Chloro-3-Cyano-Phenyl)-1,4-Dihydro-2,6-Dimethyl-Pyridine-3,5-Dicarboxylate MEMORY PHARMACEUTICALS CORPORATION 2008-01-31 US claimed
US-20050153953-A1 Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors MEMORY PHARMACEUTICAL 2005-07-14 US claimed
EP-0657430-B1 Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate BAYER AG (DE) 1999-06-02 EP claimed
US-5665740-A Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate BAYER AKTIENGESELLSCHAFT (DE) 1997-09-09 US claimed
US-20260146254-A1 Enhancing Oligonucleotide Immunomodulatory Activity through Dianophore Long-Lasting Modification: Methods and Applications SEGENA CORPORATION S.A. (UY) 2026-05-28 US disclosed
EP-4622674-A1 ENHANCING OLIGONUCLEOTIDE IMMUNOMODULATORY ACTIVITY THROUGH DIANOPHORE LONG-LASTING MODIFICATION: METHODS AND APPLICATIONS SEGENA CORPORATION S.A. (UY) 2025-10-01 EP disclosed
CN-115645389-B Application of compound ML1 and derivative thereof in improving activity and function of cerebral cortex 刘晓栋 2024-10-01 CN disclosed
US-20240016759-A1 TRANSDERMAL DELIVERY SYSTEM WITH A MICROPOROUS MEMBRANE HAVING SOLVENT-FILLEDPORES CORIUM, LLC 2024-01-18 US disclosed
US-20230391796-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF SIMON FRASER UNIVERSITY (CA) 2023-12-07 US disclosed
CN-116916916-A Glycosidase inhibitors and uses thereof 塞维利亚大学 2023-10-20 CN disclosed
US-5708177-A OXIDATION/REDUCTION OF OPPOSITE ENANTIOMERS BAYER AKTIENGESELLSCHAFT (DE) 1998-01-13 US disclosed
US-5665740-A Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate BAYER AKTIENGESELLSCHAFT (DE) 1997-09-09 US disclosed
US-5665740-A Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate BAYER AKTIENGESELLSCHAFT (DE) 1997-09-09 US disclosed
CN-1109874-A Novel substituted dihydropyridine dicarboxylic ester BAYER AG (DE) 1995-10-11 CN disclosed
CN-1109874-A Novel substituted dihydropyridine dicarboxylic ester BAYER AG (DE) 1995-10-11 CN disclosed
CN-1109874-A Novel substituted dihydropyridine dicarboxylic ester BAYER AG (DE) 1995-10-11 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230391796-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF OGA, OGT, ENGASE CYP2C9 1014/4885CYP1A2 835/4885CYP3A4 1371/4885
US-20260146254-A1 Enhancing Oligonucleotide Immunomodulatory Activity through Dianophore Long-Lasting Modification: Methods and Applications CD44, ADAR, TLR9 CYP2C9 4586/4885CYP1A2 4798/4885CYP3A4 4666/4885
US-20240016759-A1 TRANSDERMAL DELIVERY SYSTEM WITH A MICROPOROUS MEMBRANE HAVING SOLVENT-FILLEDPORES CD69, CUTA, PGRMC2 CYP2C9 444/4885CYP1A2 1082/4885CYP3A4 1041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.