Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.52 |
| ▸ | DRD4 | P21917 | 6/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858770 | 0.84 | CHRM1 (0.47) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL3277971 | 0.81 | DRD2 (0.56) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL30416496 | 0.81 | DRD2 (0.56) | CHRM1DRD2DRD4HRH4DRD3 | |
| Hydrochloric Acid SCHEMBL5445211 | 0.80 | DRD2 (0.55) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL11535134 | 0.78 | DRD2 (0.50) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL5445017 | 0.75 | CHRM1 (0.49) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL142391 | 0.71 | CHRM1 (0.75) | CHRM1DRD2DRD4HRH4DRD3 | |
| SCHEMBL11533730 | 0.69 | CHRM1 (0.71) | CHRM1DRD2DRD4HRH4DRD3 | |
| Clozapine SCHEMBL29283918 | 0.69 | DRD2 (0.95) | CHRM1DRD2DRD4HRH4DRD3 | |
| Clozapine SCHEMBL5501558 | 0.68 | DRD2 (1.00) | CHRM1DRD2DRD4HRH4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090075951-A1 | Methods and Reagents for the Treatment of Inflammatory Disorders | COMBINATORX, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| WO-2008085927-A2 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF PAIN | COMBINATORX, INCORPORATED (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075951-A1 | Methods and Reagents for the Treatment of Inflammatory Disorders | IL5, TNF, LTC4S | CHRM1 3454/4885DRD2 3820/4885DRD4 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.