Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4448345 | 0.80 | PTGS2 (0.38) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL4449234 | 0.78 | MAPT (0.45) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL4451181 | 0.74 | RAB9A (0.38) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL2925327 | 0.70 | PTGS2 (0.69) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL8053369 | 0.70 | PTGS2 (0.69) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL18790028 | 0.69 | ESR1 (0.68) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL6546605 | 0.69 | ESR1 (0.68) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL15681515 | 0.67 | PTGS2 (0.46) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL9398625 | 0.67 | PTGS2 (0.46) | PTGS2ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL30873529 | 0.65 | NQO2 (0.53) | PTGS2ALDH1A1HTTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595413-B2 | Phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2009-09-29 | — | — | US | disclosed |
| EP-1958969-A1 | A phosphine-substituted vinyl containing metallocene catalyst, preparation process and the application of the same | Petrochina Company Limited (CN) | 2008-08-20 | — | — | EP | disclosed |
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PETROCHINA COMPANY LIMITED (CN) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194854-A1 | Phosphine-substituted vinyl containing metallocene catlyst, preparation process and the application of the same | PI4K2B, PI4K2A, CPNE4 | PTGS2 3062/4885ALDH1A1 3737/4885HTT 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.