Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203169 | 0.95 | MAPT (0.53) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14322739 | 0.86 | MAPT (0.58) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL9527232 | 0.83 | ALDH1A1 (0.50) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL5090260 | 0.82 | NR4A1 (0.61) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL9530670 | 0.82 | ALDH1A1 (0.49) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL442684 | 0.82 | NR4A1 (0.56) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL29546263 | 0.82 | NR4A1 (0.56) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL2382375 | 0.80 | TDP1 (0.59) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL9526864 | 0.80 | NR4A1 (0.54) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL23651401 | 0.78 | MAPT (0.52) | MAPTALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125805-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | Astex Therapeutics Limited (GB) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075109-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |