Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389815 | 0.77 | HTR6 (0.37) | ALDH1A1ENPP3ENPP1ENPP2POLB | |
| SCHEMBL7513515 | 0.76 | MMP13 (0.40) | ALDH1A1ENPP3ENPP1ENPP2POLB | |
| SCHEMBL3386788 | 0.76 | HTR6 (0.39) | ALDH1A1ENPP3ENPP1ENPP2POLB | |
| SCHEMBL8781625 | 0.75 | ALDH1A1 (0.33) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL28453248 | 0.73 | ALDH1A1 (0.41) | ALDH1A1ENPP1PLA2G2CLMNAMAPK1 | |
| SCHEMBL28453243 | 0.73 | ALDH1A1 (0.41) | ALDH1A1ENPP1PLA2G2CLMNAMAPK1 | |
| SCHEMBL3126095 | 0.72 | TSHR (0.35) | ALDH1A1ENPP3ENPP1ENPP2POLB | |
| SCHEMBL6155399 | 0.71 | PLA2G2C (0.41) | ALDH1A1ENPP1MAPTPLA2G2CLMNA | |
| SCHEMBL3388492 | 0.71 | CA12 (0.40) | ALDH1A1FKBP1AL3MBTL1 | |
| SCHEMBL7067264 | 0.71 | PLA2G2C (0.39) | ALDH1A1ENPP1PLA2G2CLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635822-A4 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARM INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1635871-A4 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARM INC (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1635871-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | Elan Pharmaceuticals, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1635822-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | Elan Pharmaceuticals, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000244-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| WO-2005000246-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |