Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 2/20 | 0.40 |
| ▸ | HEXB | P07686 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187946 | 0.85 | KDM4E (0.51) | DNMT1RAB9ASMN1; SMN2HEXAHEXB | |
| SCHEMBL10795639 | 0.84 | DNMT1 (0.46) | DNMT1MAPTRAB9ASMN1; SMN2CYP1B1 | |
| SCHEMBL11500864 | 0.84 | ALDH1A1 (0.48) | MAPTTDP1L3MBTL1 | |
| SCHEMBL10396735 | 0.82 | BCHE (0.44) | DNMT1MAPTRAB9ASMN1; SMN2HEXA | |
| SCHEMBL4997819 | 0.82 | HEXA (0.55) | DNMT1MAPTRAB9ASMN1; SMN2HEXA | |
| SCHEMBL2641523 | 0.82 | POLB (0.60) | MAPTSMN1; SMN2HEXAHEXB | |
| SCHEMBL5953603 | 0.80 | SIRT1 (0.59) | HEXAHEXB | |
| SCHEMBL12235635 | 0.78 | CYP1B1 (0.53) | DNMT1MAPTRAB9ASMN1; SMN2CYP1B1 | |
| SCHEMBL9327695 | 0.78 | DNMT1 (0.46) | DNMT1MAPTRAB9ASMN1; SMN2CYP1B1 | |
| SCHEMBL11877346 | 0.78 | DNMT1 (0.46) | DNMT1MAPTRAB9ASMN1; SMN2HEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118065-B1 | Substituted 1H-benz[de]isoquinoline-1,3-diones | COUNCIL SCIENT IND RES (IN) | 2013-08-14 | — | — | EP | disclosed |
| EP-2118065-A1 | NOVEL SUBSTITUTED 1H-BENZ ÝDE¨ISOQUINOLINE-1, 3 -DIONES | Council of Scientific & Industrial Research (IN) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008084496-A1 | NOVEL SUBSTITUTED 1H-BENZ [DE] ISOQUINOLINE-1, 3 -DIONES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-07-17 | — | — | WO | disclosed |