Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentamethyl Melamine SCHEMBL38832 | 1.00 | LMNA (0.61) | LMNACYP1A2THRBBLMCREBBP | |
| Pentamethyl Melamine SCHEMBL15346326 | 0.97 | LMNA (0.58) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL1033226 | 0.94 | CYP1A2 (0.53) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL13599448 | 0.85 | PDE4A (0.46) | LMNACYP1A2THRBBLMCREBBP | |
| Altretamine SCHEMBL1978783 | 0.84 | LMNA (0.48) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL60190 | 0.84 | LMNA (0.42) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL11556026 | 0.84 | PDE4A (0.48) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL18737196 | 0.84 | PDE4A (0.45) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL3234910 | 0.83 | LMNA (0.42) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL9988581 | 0.80 | POLB (0.50) | LMNACYP1A2THRBBLMCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625860-B2 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S | 2009-12-01 | — | — | US | disclosed |
| US-20080081078-A1 | Prevention of Cell Proliferation by Inhibiting Myosin Light Chain Kinase | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-03 | — | — | US | disclosed |
| US-20040010001-A1 | Methods and compositions for modulating cell proliferation and cell death | AU JESSIE L-S (US) | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081078-A1 | Prevention of Cell Proliferation by Inhibiting Myosin Light Chain Kinase | MYLK3, MYLK, MYLK4 | LMNA 626/4885CYP1A2 4367/4885THRB 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.