Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008736 | 0.90 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL2006080 | 0.89 | CYP11B2 (0.46) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL2008964 | 0.85 | CYP11B1 (0.45) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL4437505 | 0.83 | SMN1; SMN2 (0.43) | CYP11B1CYP11B2CYP1A2CYP17A1SMN1; SMN2 | |
| SCHEMBL4113695 | 0.75 | CYP17A1 (0.54) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL19051717 | 0.75 | CYP17A1 (0.45) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL2007798 | 0.74 | CCR1 (0.41) | CYP11B1CYP11B2CYP1A2CYP17A1SMN1; SMN2 | |
| SCHEMBL14085859 | 0.73 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL2003406 | 0.72 | CYP11B1 (0.38) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 | |
| SCHEMBL2006806 | 0.72 | NR3C1 (0.42) | CYP11B1CYP11B2CYP1A2CYP17A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118068-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | claimed |
| WO-2008107455-A1 | INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | claimed |