Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CCR1 | P32246 | 11/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136968 | 0.89 | CYP17A1 (0.49) | CYP17A1CYP1A2CCR1NR3C1PGR | |
| SCHEMBL2006806 | 0.87 | NR3C1 (0.42) | CYP17A1CYP1A2CCR1NR3C1PGR | |
| SCHEMBL27799392 | 0.85 | CYP1A2 (0.51) | CYP17A1CYP1A2CCR1NR3C1CYP11B1 | |
| SCHEMBL19051717 | 0.84 | CYP17A1 (0.45) | CYP17A1CYP1A2NR3C1CYP11B1CYP11B2 | |
| SCHEMBL25274445 | 0.83 | XDH (0.47) | CCR1NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL30481229 | 0.83 | XDH (0.47) | CCR1NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL2008964 | 0.83 | CYP11B1 (0.45) | CYP17A1CYP1A2CCR1NR3C1PGR | |
| SCHEMBL303982 | 0.82 | CYP17A1 (0.56) | CYP17A1CYP1A2CCR1NR3C1PGR | |
| SCHEMBL2006080 | 0.81 | CYP11B2 (0.46) | CYP17A1CYP1A2CCR1NR3C1PGR | |
| SCHEMBL441028 | 0.81 | CYP1A2 (0.54) | CYP17A1CYP1A2CCR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124607-A1 | Novel Bicyclic Sulfonamides for Use as Glucocorticoid Receptor Modulators in the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2009-05-14 | — | — | US | disclosed |
| CN-101291914-A | Novel bicyclic sulfonamides for use as glucocorticoid receptor modulators in the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2008-10-22 | — | — | CN | disclosed |
| EP-1940800-A1 | NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES | Astra Zeneca AB (SE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007046747-A1 | NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124607-A1 | Novel Bicyclic Sulfonamides for Use as Glucocorticoid Receptor Modulators in the Treatment of Inflammatory Diseases | NR3C1, NR3C2, MC2R | CYP17A1 151/4885CYP1A2 579/4885CCR1 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.