Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086134 | 0.78 | CA12 (0.51) | PDE5ALTA4HALDH1A1 | |
| SCHEMBL8086133 | 0.78 | CA12 (0.51) | PDE5ALTA4HALDH1A1 | |
| SCHEMBL4459435 | 0.75 | GAA (0.48) | GAAFFAR1 | |
| SCHEMBL4458648 | 0.74 | GAA (0.47) | GAAFFAR1TNFSMN1; SMN2ALDH1A1 | |
| SCHEMBL4450871 | 0.74 | GAA (0.54) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL3657093 | 0.73 | GAA (0.57) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL1682681 | 0.73 | GAA (0.77) | GAAFFAR1PDE4DALDH1A1 | |
| SCHEMBL3658199 | 0.73 | GAA (0.57) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL3659654 | 0.72 | GAA (0.56) | GAAFFAR1TNFPDE4APDE4B | |
| SCHEMBL3655663 | 0.72 | GAA (0.56) | GAAFFAR1TNFPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |